Jan Misik Selected Research

Trimedoxime (Trimedoxime Bromide)

7/2017	The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203.
3/2017	A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats.
9/2013	Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats.

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Jan Misik Research Topics

Disease

8	Poisoning 01/2018 - 03/2010
5	Alzheimer Disease (Alzheimer's Disease) 04/2019 - 01/2016
2	Amnesia (Dissociative Amnesia) 04/2019 - 01/2018
1	Narcolepsy 01/2019
1	Sleep Wake Disorders 01/2019
1	Disease Progression 12/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2014
1	Fasciculation (Fasciculations) 11/2012
1	Pathologic Constriction (Stenosis) 02/2012
1	Necrosis 02/2012

Drug/Important Bio-Agent (IBA)

7	OximesIBA 01/2018 - 03/2010
5	tabunIBA 07/2017 - 03/2010
3	Tacrine (Cognex)FDA Link 04/2019 - 01/2016
3	Atropine FDA LinkGeneric 01/2018 - 09/2013
3	Trimedoxime (Trimedoxime Bromide)IBA 07/2017 - 09/2013
2	SarinIBA 01/2018 - 11/2012
2	asoxime chloride (H16)IBA 01/2018 - 11/2012
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2016 - 12/2015
1	LigandsIBA 04/2019
1	Tryptophan (L-Tryptophan)FDA Link 04/2019
1	Scopolamine (Hyoscine)FDA Link 04/2019
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Antidepressive Agents (Antidepressants)IBA 01/2019
1	OrexinsIBA 01/2019
1	N-Methylaspartate (NMDA)IBA 01/2019
1	Memantine (Namenda)FDA Link 01/2019
1	6-chlorotacrineIBA 01/2018
1	Quinuclidinyl BenzilateIBA 01/2018
1	AcetylcholinesteraseIBA 07/2017
1	Pharmaceutical PreparationsIBA 07/2017
1	Cholinesterases (Cholinesterase)IBA 01/2016
1	Cholinergic ReceptorsIBA 06/2014
1	Obidoxime Chloride (Obidoxime)IBA 09/2013
1	VX (EDIM)IBA 11/2012
1	Cholinergic Agents (Cholinergics)IBA 11/2012
1	SiliconesIBA 02/2012

Therapy/Procedure

2	Therapeutics 07/2017 - 01/2016
1	Stents 02/2012